L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL
1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS: 74389-68-7
Molecular Formula: C26H54NO7P
L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL - Names and Identifiers
L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL - Physico-chemical Properties
| Molecular Formula | C26H54NO7P |
| Molar Mass | 523.68 |
| Melting Point | 247 °C |
| Appearance | lyophilized powder |
| BRN | 3574588 |
| Storage Condition | -20°C |
| In vitro study | C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) elicits significant concentration-dependent neuronal loss in PAFR −/− but not PAFR +/+ cultures. C16-PAF (1 μM) elicits neuronal death in PAFR −/− cells infected with EGFP alone. C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR −/− neurons. C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits M. smegmatis and M. bovis BCG growth in a time-dependent manner. Cell Viability Assay Cell Line: Cerebellar granule neurons (CGNs) from PAFR −/− and PAFR +/+ mice Concentration: 0.5-1.5 μM Incubation Time: 24 hours Result: Elicited significant concentration-dependent neuronal loss in PAFR −/− but not PAFR +/+ cultures in serum-free media. Western Blot Analysis Cell Line: CGNs Concentration: 1 μM Incubation Time: 24 hours Result: Activated caspase 7 but not caspase 3 in PAFR −/− neurons. |
L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R38 - Irritating to the skin R40 - Limited evidence of a carcinogenic effect R48/20/22 - |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
| UN IDs | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | EC6060000 |
| FLUKA BRAND F CODES | 10-21 |
L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL - Reference Information
| Biological activity | C16-PAF (PAF (C16)) is a phospholipid medium, a platelet activating factor, and a ligand for PAF G protein coupled receptor (PAFR). C16-PAF showed anti-apoptotic effects and inhibited caspase-dependent death by activating PAFR. C16-PAF are effective MAPK and MEK/ERK activators. C16-PAF induces increased vascular permeability. |
| target | Human Endogenous Metabolite ERK MEK |
| in vitro study | C16-PAF (PAF (C16); 0.5-1.5 μM; For 24 hours) elicits significant concentration-dependent neuronal loss in PAFR −/but not PAFR / cultures. C16-PAF (1 μM) elicits neuronal death in PAFR −/cells infected with EGFP alone. C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR/neurons. C16-PAF is synthesized by two distinct pathways; The remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits M. smegmatis and M. bovis BCG Growth in a Time-dependent Manner. Cell Viability Assay Cell Line: Cerebellar granule neurons (CGNs) from PAFR/and PAFR/MICE Concentration: 0.5-1.5 μM Incubation Time: 24 Hours Result: elicited significant concentration-dependent neuronal loss in PAFR/but not PAFR / cultures in series-free media. Western Blot Analysis Cell Line: CGNs Concentration: 1 μM Incubation Time: 24 hours Result: Activated caspase 7 but not caspase 3 in PAFR/neurons. |
| Cell Line: | Cerebellar granule neurons (CGNs) from PAFR −/− and PAFR +/+ mice CGNs |
| Concentration: | 0.5-1.5 μM 1 μM |
| Incubation Time: | 24 hours 24 hours |
| Result: | Elicited significant concentration-dependent neuronal loss in PAFR −/− but not PAFR +/+ cultures in serum-free media. Activated caspase 7 but not caspase 3 in PAFR −/− neurons. |
Last Update：2024-04-09 18:58:34
Supplier List
Product Name: 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE Visit Supplier Webpage Request for quotation
CAS: 74389-68-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 74389-68-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE Visit Supplier Webpage Request for quotation
CAS: 74389-68-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 74389-68-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History